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Fentanyl 25 µg/uur Teva

The concomitant use of transdermal fentanyl with CYP3A4 inducers may result in a decrease in fentanyl plasma concentrations and a decreased therapeutic effect. Caution is advised upon concomitant use of CYP3A4 inducers and Durogesic DTrans.

£80.00

DESCRIPTION

Fentanyl transdermal system is a transdermal system providing continuous systemic delivery of fentanyl, a potent opioid analgesic, for 72 hours. The chemical name is N-Phenyl-N-(1-(2-phenylethyl)-4-piperidinyl) propanamide. The structural formula is:

Chemical Structure

The molecular weight of fentanyl base is 336.5, and the molecular formula is C22H28N2O. The n-octanol:water partition coefficient is 860:1. The pKa is 8.4.

System Components and Structure

The amount of fentanyl released from each system per hour is proportional to the surface area (25 mcg/hr per 7.8 cm2). The composition per unit area of all system sizes is identical.

* Nominal delivery rate per hour

Dose*
(mcg/hr)
Size
(cm2)
Fentanyl Content
(mg)
25 7.8 2.75
50 15.6 5.50
75 23.4 8.25
100 31.2 11.0

Fentanyl transdermal system is a rectangular transparent unit comprising a protective liner and four functional layers. Proceeding from the outer surface toward the surface adhering to skin, these layers are:

  1. a backing layer of PET foil;
  2. a drug-containing layer of fentanyl and dipropylene glycol with hydroxypropyl cellulose;
  3. an ethylene vinyl-acetate copolymer membrane that controls the rate of fentanyl delivery to the skin surface; and
  4. a silicone adhesive. Before use, a protective liner covering the adhesive layer is removed and discarded.

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